PEER-REVIEWED · PUBLISHED IN mSYSTEMS · 296 PARTICIPANTS

Gut support,
built for
autistic people.

Many autistic children and adults live with GI pain, constipation, and bloating. Autism Probiotics builds a personalized probiotic from your own gut microbiome data to support digestive health — not a generic capsule from a shelf. It supports gut health; it is not a treatment for autism.

296

Autistic participants enrolled

170

Completed the 3-month pilot

↑

Significant increase in gut microbiome diversity

↓

Significant reduction in GI symptom severity

WHAT THE OPEN-LABEL PILOT REPORTED

Gut diversity

Significant increase ↑

GI symptoms

Significant reduction ↓

Source: Phan et al., “Precision synbiotics increase gut microbiome diversity and improve gastrointestinal symptoms in a pilot open-label study for autism spectrum disorder,” mSystems (ASM), 2024. Open-label pilot, n=170 completers — not a randomized controlled trial, and not a test of autism symptoms.

Gut health is real health. Let's start there.

GI issues are common in autistic people, and discomfort can make everything else harder. We don't make promises about autism — we build an individualized probiotic from real microbiome data to support digestive health, and a clinician reviews every single formula.

40,000+ PERSONALIZED FORMULATIONS · EVERY FORMULA CLINICIAN-REVIEWED

THE CLINICAL EVIDENCE

Real data. Real families. An honest look at the research.

Published in mSystems (2024) by researchers at Arizona State University and Flore. The largest study of its kind on personalized probiotics and autism. Read the full paper · Our deep dive

296

Autistic participants enrolled

170 completed the full study

GI↓

Significant reduction in GI symptom severity

Over 3 months (open-label pilot)

0.936

Research classification model (AUC)

Autism vs. non-autistic microbiome across 15,249 whole-genome samples — a research model, not a diagnostic

123

Neurotypical controls

Age-matched comparison group

Phan et al. “Precision synbiotics increase gut microbiome diversity and improve gastrointestinal symptoms in a pilot open-label study for autism spectrum disorder.” mSystems (ASM), 2024. An open-label pilot — not a randomized controlled trial. PMC11097633

WHAT THE RESEARCH FOUND

What the open-label pilot reported.

GI symptoms eased

The pilot reported a statistically significant reduction in gastrointestinal symptom severity (GSRS) over 3 months. When a child's stomach stops hurting, daily life gets a little more possible.

Gut microbiome diversity increased

Participants' gut bacteria became significantly more diverse over 3 months (Shannon diversity, richness, evenness). Higher diversity is a widely used marker of gut-microbiome health.

Honest about what it is

This was an open-label pilot, not a randomized controlled trial, and it did not measure or establish any effect on autism itself. Autism Probiotics supports gut health — it does not treat, cure, or change autism.

Built for one person, not everyone

Each formula is individually manufactured from your own microbiome data. Not a generic supplement. Not an algorithm picking from a menu. A formula built from scratch and reviewed by a clinician.

WHO THIS IS FOR

For autistic people living with gut issues.

Autistic children, teens, and adults are more likely to experience GI problems than non-autistic people. That discomfort is real, it's often hard to communicate, and it deserves care on its own terms — which is exactly what this is for.

GI pain and discomfort

Constipation, diarrhea, bloating, reflux — and not always the words to describe them. GI symptoms are common in autistic people, and the pilot reported a significant reduction in GI symptom severity over 3 months.

Restricted diets

Limited food acceptance can narrow the microbiome. A personalized synbiotic adds targeted probiotic strains and prebiotic fiber that a selective diet may be missing.

A gut microbiome out of balance

Research finds autistic and non-autistic gut microbiomes often differ in composition and diversity. This builds a formula from your own data to support a more diverse, balanced gut.

Families and caregivers

This isn't a cure, and we won't pretend it is. It's a personalized, clinician-reviewed probiotic focused on gut health, backed by a published open-label pilot. If GI issues are part of your daily life, it's worth a look.

TWO WAYS TO START

No stool sample required.
Start in 5 minutes.

NO LAB WORK NEEDED

Tell us what's happening

GI symptoms, diet, behaviors, daily challenges — answer what you can. We'll build a formula personalized to your child from there. A clinician reviews every one.

Start the assessment

HAVE LAB RESULTS?

Upload your report

Microbiome test, GI panel, stool analysis — upload whatever you have from your provider. We'll formulate a precision blend from your actual data.

Upload a report

HOW IT WORKS

Simple process.
Precise support.

The same approach from the 296-participant ASU study. Built for your child. Shipped to your door.

Share the details

Upload a lab report or answer our assessment. We capture diet, GI patterns, sensory details, and health history to understand the full picture.

About 5 minutes

We formulate

Our team builds a custom probiotic + prebiotic blend targeting specific microbiome gaps. Up to 2,300 species analyzed. Nothing generic.

Precision blend

Delivered to your door

Your personalized formula arrives ready to go. Track progress, adjust the formula as things evolve, and watch things shift.

Ongoing support

Precision probiotics vs. generic supplements

Feature	Autism Probiotics	Generic Probiotics
Formulated from microbiome data	✓	✗
Backed by autism clinical study	✓	✗
Up to 2,300 species analyzed	✓	✗
Formula evolves with progress	✓	✗
No stool sample required	✓	—
Works from labs or symptoms	✓	✗
One-size-fits-all approach	✗	✓

Gut health, taken seriously. Backed by published research.

296 autistic participants. Peer-reviewed. A significant increase in gut diversity and a reduction in GI symptoms in an open-label pilot. Each formula is built for one person and reviewed by a clinician — to support gut health, not to treat autism.

Gut support,built forautistic people.